LABORATORY REVIEW
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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PI3-kinase
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adenylyl cyclase
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phospholipase C-beta
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Detailed explanation-1: -Gq proteins couple to G protein-coupled receptors to activate beta-type phospholipase C (PLC-) enzymes.
Detailed explanation-2: -Gq family members of heterotrimeric G protein activate ß isoforms of phospholipase C that hydrolyzes phosphati-dylinositol phosphate to diacylglycerol and inositol tris-phosphate, leading to the protein kinase C activation and intracellular Ca 2+ mobilization, respectively.
Detailed explanation-3: -G protein-coupled receptor kinase 2–a feedback regulator of Gq pathway signalling. Curr Drug Targets Immune Endocr Metabol Disord.
Detailed explanation-4: -Phospholipases C beta (PLC-s) are essential components of the signal transduction of metazoans. They catalyze the production of the second messengers inositol-1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG) from the hydrolysis of phosphatidylinositol-4, 5-bisphosphate (PIP2).