AP BIOLOGY

Detailed explanation-1: -Abstract. Many bacterial plasmids replicate by a rolling-circle (RC) mechanism. Their replication properties have many similarities to as well as significant differences from those of single-stranded DNA (ssDNA) coliphages, which also replicate by an RC mechanism.

Detailed explanation-2: -Replication of plasmid deoxyribonucleic acid (DNA) is dependent on three stages: initiation, elongation, and termination. The first stage, initiation, depends on plasmid-encoded properties such as the replication origin and, in most cases, the replication initiation protein (Rep protein).

Detailed explanation-3: -Rolling circle replication (RCR) is a unidirectional nucleic acid replication mechanism that may rapidly create multiple copies of circular molecules of DNA or RNA, such as plasmids, bacteriophage genomes, and the circular RNA genome of viroids.

Detailed explanation-4: -As with other rolling-circle replicons, MSV replication is discontinuous with virion strand replication being initiated from the hairpin structure in the LIR and complementary strand synthesis being initiated from a short 80 nt primer-like molecule synthesized on the SIR of newly replicated virion strands. Figure 6.