LABORATORY REVIEW
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The order of amino acids is changed when the protein overheats.
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The bonds between amino acids are broken by condensation.
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Parts of the protein become linked together by hydrolysis.
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The three-dimensional structure of the protein is altered.
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Detailed explanation-1: -During the denaturation of proteins, the secondary and tertiary structures get destroyed and only the primary structure is retained. Covalent bonds are broken and interaction between amino-acid chains gets disrupted. This results in the loss of biological activity of the proteins.
Detailed explanation-2: -Denaturation and protein folding If the temperature or pH of a protein’s environment is changed, or if it is exposed to chemicals, these interactions may be disrupted, causing the protein to lose its three-dimensional structure and turn back into an unstructured string of amino acids.
Detailed explanation-3: -As a result of denaturation, globules get unfolded and helixes get uncoiled. Secondary and tertiary structures of protein are destroyed, but the primary structures remain unaltered. It can be said that during denaturation, secondary and tertiary-structured proteins get converted into primary-structured proteins.
Detailed explanation-4: -The amino acid sequence of a protein determines its three-dimensional shape.
Detailed explanation-5: -Denaturation breaks the covalent bonds that hold the protein in its three-dimensional shape. Without the proper shape, the protein cannot function. Denaturation destroys the primary structure of the protein, and the protein breaks down to monomers.