THE CELL
CELL COMMUNICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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cancer cells are in G0
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cancer cells are arrested in the S phase
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cell cycle check points are not in place
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transformation introduces new chromosomes to cells
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Detailed explanation-1: -Cancer cells are notorious for their genetic disarray. A tumor cell can contain an abundance of DNA mutations and most have the wrong number of chromosomes. A missing or extra copy of a single chromosome creates an imbalance called aneuploidy, which can skew the activity of hundreds or thousands of genes.
Detailed explanation-2: -Checkpoints are mechanisms that regulate progression through the cell cycle insuring that each step takes place only once and in the right sequence. Mutations of checkpoint proteins are frequent in all types of cancer as defects in cell cycle control can lead to genetic instability.
Detailed explanation-3: -The Challenge: Normal cells have 46 chromosomes, but cancer cells often have fewer or extra chromosomes. Some advanced tumors can even have cancer cells with up to 100 chromosomes. A missing or extra copy of chromosomes creates an imbalance called aneuploidy.
Detailed explanation-4: -Chromosomal Instability (CIN) 9, 31 CIN and aneuploidy are deemed common features of cancer that involve gain or loss of chromosomes. CIN is the process that leads to chromosome copy number alterations and thereby results in aneuploidy.