AP BIOLOGY

Detailed explanation-1: -If cells in the process of dividing are subjected to colchicine, a drug that interferes with the functioning of the spindle apparatus, at which stage will mitosis be arrested? The answer is at the metaphase stage of mitosis when the spindle apparatus has failed to properly position chromosomes.

Detailed explanation-2: -Answer and Explanation: Colchicine is a drug that interferes with mitotic cell division during the cell cycle. Colchicine hinders the production of spindle fibers, and hence metaphase does not progress, and the cell cycle stops at this stage.

Detailed explanation-3: -Colchicines prevent spindle formation during mitotic metaphase. Thus, it prevents the separation of chromosomes during anaphase stage.

Detailed explanation-4: -Colchicine is a mitotic inhibitor, so it inhibits the M phase or mitotic phase. Q. Drugs such as vincristine and colchicine disrupt mitosis by binding to tubulin and interferes with microtubule assembly and disassembly.

Detailed explanation-5: -At a cellular level, colchicine is an antimitotic agent that inhibits mitosis by preventing the polymerization of tubulin, 11, 12 a constituent microtubule protein, thereby disturbing those processes dependent on microtubule function such as cell motility, intracellular movement, cell polarity, and mitosis.