THE CELL
CELL COMMUNICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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If Herceptin is found in the breast lymph nodes of the patient.
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If the patient’s cancer cells have detectable HER2.
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If the patient’s genome codes for the HER2 receptor.
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If HER2, administered by injection, is in sufficient concentration.
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Detailed explanation-1: -So, the correct answer is ‘Herceptin works by attaching itself to the HER receptors on the surface of breast cancer cells and blocks them from receiving growth signals. By blocking growth signals, Herceptin can slow or stop the growth of breast cancer for patients with high levels of HER receptors’
Detailed explanation-2: -Importantly, RTKs are key regulators of cancer stemness and associated with drug resistance in breast cancer cells. In general, various RTKs activate PI3K/Akt signaling to induce the expression of cancer stemness factors, multidrug resistance associated proteins and membrane transporters in cancer cells.
Detailed explanation-3: -Receptor tyrosine kinases (RTKs) are a subclass of tyrosine kinases that are involved in mediating cell-to-cell communication and controlling a wide range of complex biological functions, including cell growth, motility, differentiation, and metabolism.
Detailed explanation-4: -Receptor tyrosine kinase (RTK) activation regulates many key processes including cell growth and survival. However, dysregulation of RTK has been found in a wide range of cancers, and it has been shown to correlate with the development and progression of numerous cancers.
Detailed explanation-5: -G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) are transmembrane receptors that initiate intracellular signaling cascades in response to a diverse array of ligands.