AP BIOLOGY

Detailed explanation-1: -Sonic Hedgehog is necessary for the development of the front part of the brain (forebrain). This signaling protein helps establish the line that separates the right and left sides of the forebrain (the midline). Specifically, Sonic Hedgehog establishes the midline for the underside (ventral surface) of the forebrain.

Detailed explanation-2: -Sonic Hedgehog (Shh) signalling pathway is one of the major trafficking networks that regulates the key events during developmental processes i.e growth and patterning of multicellular embryos.

Detailed explanation-3: -Endodermal expression patterns of Sonic hedgehog (SHH), a potent intercellular signaling protein, demarcate a molecular boundary between pancreas and adjacent stomach and duodenal anlagen (9–12). Shh is expressed at high levels in stomach and duodenal endoderm but repressed in pancreas endoderm.

Detailed explanation-4: -The hedgehog signaling pathway is a mechanism that directs the development of embryonic cells in animals, from invertebrates to vertebrates. The hedgehog signaling pathway is a system of genes and gene products, mostly proteins, that convert one kind of signal into another, called transduction.