The Notch Receptor pathway is involved in determining what types of cells will form during embryonic development. The Notch receptors in the membrane bind to ligands on the membranes of adjacent cells in this pathway.

CELL COMMUNICATION

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

A	autocrine signalling
B	juxtacrine signalling
C	paracrine signalling
D	endocrine signalling

Explanation:

Detailed explanation-1: -The Notch pathway regulates cell proliferation, cell fate, differentiation, and cell death in all metazoans.

Detailed explanation-2: -Primary Notch target genes include two families of transcriptional factors Hes, including HES1 and HES5 as well as Hey including HEY1 and HEY2. Other Notch target genes include CCND1, CDKN1A, GATA3 and PTCRA. CNTN1 acts as a functional ligand of Notch.

Detailed explanation-3: -Notch signalling has been shown to be a niche factor required for maintenance of GI stem cells in both tissues. In addition, Notch has been described to regulate epithelial cell differentiation.

Detailed explanation-4: -The pathway encompasses 4 Notch receptor paralogues (Notch1–4) and 5 ]Notch ligands(Jagged1 [JAG1], Jagged2 [JAG2], Delta-like ligand 1 [DLL1], Delta-like ligand 3 [DLL3] and Delta-like ligand 4 [DLL4]) in mammals. The pathway is initially activated by occupation of the representative Notch receptor.

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AP BIOLOGY

THE CELL

CELL COMMUNICATION