THE CELL
CELL COMMUNICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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modifies a G protein involved in regulating salt and water secretion.
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signals inositol trisphosphate to become a second messenger for the release of calcium.
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modifies calmodulin and activates a cascade of protein kinases.
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Detailed explanation-1: -A bacterium called Vibrio cholerae causes cholera infection. The deadly effects of the disease are the result of a toxin the bacteria produces in the small intestine. The toxin causes the body to secrete enormous amounts of water, leading to diarrhea and a rapid loss of fluids and salts (electrolytes).
Detailed explanation-2: -Cholera toxin, by acting as a classical A-B type toxin, leads to ADP-ribosylation of G protein, and constitutive activation of AC, thereby giving rise to increased levels of cyclic AMP within the host cell (Fig. 1).
Detailed explanation-3: -Cholera toxin enhances the growth of Vibrio cholerae in the gut lumen by increasing available iron and fatty acid nutrients. Cholera toxin (CTX) facilitates the devastating clinical manifestations of Vibrio cholerae infection and promotes the massive secretory diarrhea that causes considerable spread of the pathogen.
Detailed explanation-4: -Cholera toxin (CT) is a bacterial protein toxin produced by Vibrio cholerae, which binds to cellular membranes with high affinity.