THE CELL
CELL COMMUNICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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epinephrine binding to it
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an activated G protein
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cAMP
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a protein kinase
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Detailed explanation-1: -Adenylyl cyclase can be activated directly by forskolin, a plant diterpene which has been useful in studies of enzyme regulation and purification. The substrate for adenylyl cyclase is a complex of Mg2+ and ATP.
Detailed explanation-2: -GTP-bound Gs alpha then binds to and stimulates adenylyl cyclase. Adenylyl cyclase is a membrane-bound enzyme that catalyzes the conversion of ATP to cAMP. [1] cAMP, an intracellular second messenger, activates protein kinase A by dissociating its regulatory subunit from the catalytic subunit.
Detailed explanation-3: -Evidence suggests that both alpha and beta gamma subunits of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) inhibit adenylyl cyclase.