AP BIOLOGY

THE CELL

STRUCTURE AND FUNCTION OF THE CELL

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Many classes of antibiotics function by increasing membrane permeability in bacteria. What effect would this have on the bacterium?
A
The cell would have difficulty maintaining homeostasis
B
The cell would grow too large to function efficiently
C
The cell would have an increased rate of ATP production
D
The cell is now more susceptible to phagocytic white blood cells.
Explanation: 

Detailed explanation-1: -b | Antibiotic exposure disrupts epithelial homeostasis. Subsets of the normal microbiota are lost, thus reducing epithelial exposure to microbiota-derived MAMPs. Fewer MAMPs result in decreased host–microbiota signalling (that is, decreased PRR stimulation), which leads to decreased AMP production by IECs.

Detailed explanation-2: -Hydrophobic antibiotics that appear to gain access to the cell interior by permeating through the OM bilayer per se are aminoglycosides (gentamycin, kanamycin), macrolides (erythromycin), rifamycins, novobiocin, fusidic acid and cationic peptides [11, 14].

Detailed explanation-3: -Disrupting the plasma membrane causes rapid depolarization, resulting in a loss of membrane potential leading to inhibition of protein, DNA and RNA synthesis, which leads to bacterial cell death.

Detailed explanation-4: -Answer and Explanation: The statement that describes the effect of the antibiotic on cellular homeostasis is antibiotics interface with the transport of intracellular and extracellular materials.

There is 1 question to complete.