THE HUMAN IMMUNE SYSTEM
AIDS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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It bypasses the T cells and begins reproducing in the bloodstream
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It directly attacks the T cells
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It begins producing T cells of its own
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It disguises itself as a T cell
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Detailed explanation-1: -HIV binds to the CD4 molecule on the surface of helper T-cells and replicates within them. This results in destruction of CD4+ T-cells and leads to a steady decline in this population of T-cells.
Detailed explanation-2: -HIV enters its genetic information into helper T cells to make copies of itself. When this happens, the helper T cells die. This severely disrupts the immune response. Low levels of helper T cells mean killer T cells and other white blood cells do not receive as much information about pathogens in the body.
Detailed explanation-3: -This is because HIV hides from the body’s immune system in a group of immune cells called CD4 lymphocytes, also known as the HIV reservoir. While HIV is latent in the reservoir, meaning it doesn’t replicate, it can wake up, causing viral load to increase and making a cure elusive.
Detailed explanation-4: -In HIV infection, the activation of CD4+ T cells is driven by the antigenic stimulus by HIV proteins (110) and in part by antigen-independent mechanisms through the production of inflammatory cytokines.
Detailed explanation-5: -When HIV infects a cell, it first attaches to and fuses with the host cell. Then the virus uses the host cell’s machinery to convert the viral RNA into DNA and replicate itself. The new copies of HIV then leave the host cell and move on to infect other cells.