AP BIOLOGY

THE HUMAN IMMUNE SYSTEM

AIDS

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

In a patient with clinical signs of primary immunodeficiency, violations of the function of antigen presentation of immunocompetent cells were detected. Defect structures of which cells are possible?

A	Macrophages, monocytes
B	T-lymphocytes
C	B-lymphocytes
D	Fibroblasts

Explanation:

Detailed explanation-1: -Decreased mannose binding lectin (MBL) is the most common immunodeficiency in humans, with 5% of the population affected. Although the phenotype of this deficiency is usually mild, an increased prevalence of SLE has been reported in these patients [50].

Detailed explanation-2: -IgA deficiency is the most common PID, occurring in approximately 1 in 300 to 1 in 500 persons [4]. The clinical presentation of PIDs is highly variable; however, most disorders involve increased susceptibility to infection.

Detailed explanation-3: -People with primary immunodeficiency (PI) have an immune system that does not work correctly. This means that people with PI are more likely to get and become very sick from infections. There are more than 400 types of PI that vary in severity, which affects how early they are detected.

There is 1 question to complete.