THE HUMAN IMMUNE SYSTEM
BLOOD GROUPS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Fy a
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Fy b
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Fy3
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Fy6
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Detailed explanation-1: -M and N antigens are antithetical and sensitive to enzyme treatment including ficin, papain, trypsin, and pronase; these properties can aid in antibody identification.
Detailed explanation-2: -The Duffy blood group system is a complex of highly immunogenic glycoprotein antigens found on the surface of red blood cells (RBC), vasculature endothelial cells, alveolar epithelial cells, collecting tubules of the kidney, and on the surface of Purkinje cells in the brain.
Detailed explanation-3: -Enzyme treatment: This will enhance the reactivity of Rh, I, P, Lewis, and Kidd antibodies. However, these enzymes will also destroy M, N, S, s, and Fy antigens.
Detailed explanation-4: -The two main alleles, FYA and FYB, differ by a single nucleotide at position 125 (G and A, respectively) and they likewise encode Fya and Fyb antigens that differ by a single amino acid at residue 42 (glycine and aspartic acid, respectively).