AP BIOLOGY

Detailed explanation-1: -B cell development starts in the bone marrow (BM) and continues in the spleen to final maturation. Developmental progression is guided by sequential events leading to assembly, expression, and signaling of the B cell antigen receptor (BCR).

Detailed explanation-2: -Inside the bone marrow, blood stem cells divide and mature to make new blood cells. During this process, the cells become either lymphocytes (a kind of white blood cell) or other blood-forming cells. These other blood-forming cells mature into red blood cells, white blood cells (other than lymphocytes), or platelets.

Detailed explanation-3: -These studies indicate that IgDhi B cells normally mature contemporaneously in the bone marrow and the spleen. They also formally establish that B cells in the bone marrow can be activated by blood-borne microbes in the absence of all secondary lymphoid organs.

Detailed explanation-4: -Additionally, B cells present antigens (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines. In mammals, B cells mature in the bone marrow, which is at the core of most bones.

Detailed explanation-5: -A type of white blood cell that makes antibodies. B cells are part of the immune system and develop from stem cells in the bone marrow. Also called B lymphocyte.