AP BIOLOGY

Detailed explanation-1: -During diapedesis, neutrophils squeeze through gaps between adjacent endothelial cells of blood capillaries and enter the tissue. After the neutrophils have entered the tissue, they move toward the infection by the process of chemotaxis.

Detailed explanation-2: -Neutrophils may neutralize and clear bacteria and damaged cells through phagocytosis, release of net extracellular traps (NETs), or necroptosis. Phagocytosis induces apoptosis in PMNs, followed by removal of apoptotic cells by macrophages through efferocytosis.

Detailed explanation-3: -Other chemicals released by damaged cells attract phagocytes (chemotaxis) which are able to squeeze through the gaps in the leaky capillary walls (a process called diapedesis). Neutrophils arrive first but are replaced by macrophages in major infections.

Detailed explanation-4: -The process in which the phagocytes squeeze through the cells is known as diapedesis. The diapedesis is the process in which the shape of the phagocytic cell changes so that it can moe through the pores between endothelial cells.