THE HUMAN IMMUNE SYSTEM
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Ig G
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Ig M
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Ig A
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Ig D
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Detailed explanation-1: -Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains.
Detailed explanation-2: -Immunoglobulin G (IgG) is one of the most abundant proteins in human serum, accounting for about 10–20% of plasma protein. It is the major class of the five classes of immunoglobulins in human beings, IgM, IgD, IgG, IgA, and IgE.
Detailed explanation-3: -IgM is the largest antibody and the first one to be synthesized in response to an antigen or microbe, accounting for 5% of all immunoglobulins present in the blood.
Detailed explanation-4: -Serum immunoglobulins (IgG, IgA and IgM) levels were determined by a commercial nephelometry assay using a BN-II device (Dade Behring, Marburg, Germany). The manufacturer indicates the following reference intervals for healthy adults: IgA 70–400 mg/dl, IgG 700–1600 mg/dl and IgM 40–230 mg/dl [35].
Detailed explanation-5: -There are 5 types of antibodies found: IgG, IgA, IgE, IgM, and IgD. The most abundant antibody is IgG. It is 75% of total antibodies.