THE HUMAN IMMUNE SYSTEM
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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CD28
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LFA-1
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CD20
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CD26
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Detailed explanation-1: -In humans, CD28 is expressed on approximately 80% of CD4+ T cells and 50% of CD8+ T cells and has been detected on plasma cells, neutrophils, and eosinophils. In contrast to humans, in mouse 100% of both CD4 and CD8 T cells express CD28.
Detailed explanation-2: -CD28 acts as a activator and CTLA4 acts as inhibitor. ICOS and CD28 are also closely related genes, but they cannot substitute from one another in function.
Detailed explanation-3: -Loss of CD28 expression on T lymphocytes: a marker of replicative senescence.
Detailed explanation-4: -Recent studies demonstrated the existence of at least two ligands on accessory cells, CD80 (B7-1) and CD86 (B7-2). In this study we demonstrate that, although CD80 and CD86 are both expressed on monocytes, they seem to have different functions. Freshly isolated monocytes express CD86 but are CD80-negative.