THE HUMAN IMMUNE SYSTEM
IMMUNE RESPONSE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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CTL and Target cell
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Macrophage and T-Cell
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B-Cell and T-Cell
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Any APC to T-Cell
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Detailed explanation-1: -The immunological synapse forms as a result of the tight apposition of a T cell with an antigen-presenting cell (APC) and it is the site where the T-cell receptor (TCR) is triggered by its antigen ligand, the peptide–MHC complex present in the APC membrane.
Detailed explanation-2: -There are two types of T cell receptor (TCR); alpha beta and gamma delta, both of which are composed of a heterodimer and associated with invariant CD3 complexes on the cell surface.
Detailed explanation-3: -The immunological synapse (IS) is a stable cell–cell junction between a thymus-derived lymphocyte (T cell) and an antigen-presenting cell (APC). The IS concept provides a number of insights into the T cell activation process. Firstly, it provides a stop signal that coordinates antigen recognition and T cell migration.
Detailed explanation-4: -The immunological synapse or kinapse integrates three broad categories of receptors: antigen (TCR), adhesion, and costimulatory/checkpoint. The organization of these receptors in the interface impacts how they function in a way that cannot be predicted without this spatial and temporal information.
Detailed explanation-5: -Cytotoxic T cells recognize antigen bound to MHC protein type 1.