AP BIOLOGY

THE HUMAN IMMUNE SYSTEM

TRANSFUSION

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
In the process of intravascular lysis of red blood cells, what stages occur?
A
Heme and Fe are carried to the liver
B
Macrophages phagocytize Ag and Ab
C
C5b, C6, C7, C8 and C9 make up MAC
D
Bilirubin will be excreted through the kidneys
E
Reaction between donor and recipient T lymphocytes
Explanation: 

Detailed explanation-1: -Intravascular hemolysis is the destruction of red blood cells in the circulation with the release of cell contents into the plasma. Mechanical trauma from a damaged endothelium, complement fixation and activation on the cell surface, and infectious agents may cause direct membrane degradation and cell destruction.

Detailed explanation-2: -CD55 and CD59 are glycosylphosphatidylinositol-anchored proteins with regulatory properties on the activating cas-cades of the complement system. This regulation occurs through inhibition of the C3-convertase formation by CD55, and prevention of the terminal polymerization of the membrane attack complex by CD59.

Detailed explanation-3: -Intravascular hemolysis involves cell destruction that happens within your blood vessels. With intravascular hemolysis, the parts of the destroyed cells circulate within your blood.

Detailed explanation-4: -Intravascular hemolysis results in circulating free hemoglobin. If the hemolysis is mild, the released hemoglobin is bound by circulating haptoglobin. With massive hemolysis, however, haptoglobin becomes exhausted.

There is 1 question to complete.