THE HUMAN IMMUNE SYSTEM
TRANSFUSION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Rh
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Duffy
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I have to
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Luthern
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Detailed explanation-1: -In contrast to intravascular hemolysis, this is the type of hemolysis typically seen when IgG antibodies (instead of IgM) coat incompatible RBCs. Since IgG isn’t generally great at activating the complement system, these antibodies do not immediately destroy the target RBCs.
Detailed explanation-2: -Intravascular hemolysis is most commonly caused by antibodies that are capable of activating the complement system, so as a result, the antibodies are most often IgM antibodies that react at body temperatures rather than IgG.
Detailed explanation-3: -IgG bound to a RBC can mark the RBC for extravascular destruction, which occurs in the reticuloendothelial system (RES, also known as mononuclear phagocyte system) of primarily the spleen and liver and is effected by macrophages (Fig. 1).
Detailed explanation-4: -Autoimmune hemolytic anemia and hereditary spherocytosis are examples of extravascular hemolysis because the red blood cells are destroyed in the spleen and other reticuloendothelial tissues.