THE HUMAN IMMUNE SYSTEM
TRANSFUSION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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In the vast majority of cases, CLL is CD5<0
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In the vast majority of cases, CLL is CD23 >0
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In the vast majority of cases, follicular lymphoma is CD10 >0
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In the vast majority of cases, marginal zone lymphoma is CD10 >0
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Detailed explanation-1: -Some forms of DLBCL can also be CD10-positive. Positive CD10 expression in more than 30 percent of cancer cells classifies a patient with DLBCL as having a particular subtype (GC, or germinal center type), which has a better overall survival rate than that the non-GC phenotype.
Detailed explanation-2: -The CD10 positive stromal cells are present at the cancer cells invasive front suggests the interaction between breast cancer cells and CD10-positive stromal cells. Moreover, presence of CD10 on stromal cells positively correlates with nodal metastasis, tumor grade, tumor size, lymph node and worsening prognosis.
Detailed explanation-3: -In a normal lymph node, CD10 (CALLA) expression is generally confined to reactive germinal centers (i.e. secondary follicles), with occasional scattered positive lymphocytes in the interfollicular areas. Stromal cells are also frequently positive, as are neutrophils.
Detailed explanation-4: -By contrast, CD10-negative ALL cells have lower c-myc levels and inferior cycling and apoptotic properties under the same in vitro conditions. CD10-positive ALL comprise different subgroups characterised by distinctive cytogenetic abnormalities.