THE HUMAN IMMUNE SYSTEM
TRANSFUSION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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the LLC
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follicular lymphoma
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le lymphoma de Waldenström
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diffuse large B-cell lymphoma
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Detailed explanation-1: -Alemtuzumab. Alemtuzumab is a recombinant, fully humanized, monoclonal antibody against CD52. The moderate effectiveness of alemtuzumab in patients with high-risk genetic markers such as del(17p) and TP53 mutations has been proven.
Detailed explanation-2: -[1] Li-Fraumeni syndrome (LFS) is an inherited autosomal dominant disorder that is usually associated with abnormalities in the tumor suppressor protein P53 gene (TP53) located on chromosome 17p13. [2] It is also known as the sarcoma, breast, leukemia, and adrenal gland (SBLA) cancer syndrome.
Detailed explanation-3: -When TP53 mutations are inherited, they cause LFS, a disease that leaves people with a 90 percent chance of developing cancer in their lifetime.
Detailed explanation-4: -TP53 gene mutations change single amino acids in p53, which impair the protein’s function. Without functioning p53, cell proliferation is not regulated effectively and DNA damage can accumulate in cells. Such cells may continue to divide in an uncontrolled way, leading to tumor growth.