AP BIOLOGY

Detailed explanation-1: -Thus, extravascular hemolysis will result in increased presentation of unconjugated bilirubin to the hepatocyte.

Detailed explanation-2: -In hemolysis, the concentration of unconjugated bilirubin (indirect bilirubin) is increased, while in liver disease the level of conjugated bilirubin (direct bilirubin) is increased. However, if the patient has concomitant liver disease with an increased direct bilirubin level, the serum bilirubin test is not reliable.

Detailed explanation-3: -Extravascular hemolysis leads to splenomegaly, jaundice, and increased risk of pigmented (bilirubin) gallstones. Intravascular hemolysis releases hemoglobin into the plasma; chronically, this can lead to renal damage.

Detailed explanation-4: -Extravascular hemolysis involves red blood cell destruction that takes place outside of your blood vessels. Blood vessels include veins, arteries and capillaries. Your spleen is the most common site of extravascular hemolysis.

Detailed explanation-5: -Common causes of higher indirect bilirubin include: Hemolytic anemia. This means your body is getting rid of too many red blood cells. Bleeding into the skin caused by injury.