AP BIOLOGY

THE HUMAN IMMUNE SYSTEM

TRANSFUSION

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which of the following DEAs will react most severely when the recipient dog has an antibody?
A
DEA-1
B
DEA-4
C
DEA-6
D
DEA-7
Explanation: 

Detailed explanation-1: -The most commonly found blood type is DEA 1.1 which means that those dogs may only safely donate to other dogs who have DEA 1.1. Greyhounds, Boxers, Irish Wolfhounds, German Shepherds, Dobermans, and Pit Bulls are generally DEA 1.1 negative. Breeds more commonly DEA 1.1 positive are Golden Retrievers and Labradors.

Detailed explanation-2: -The more clinically relevant canine blood type is DEA 1.1 since it’s associated with the strongest antigenic response and the more severe blood transfusion reaction. The canine red blood cells are either positive or negative for a specific blood type (e.g.DEA 4+ or DEA 4-). Approximately 45% of dogs are DEA 1.1+.

Detailed explanation-3: -Dog Erythrocyte Antigens (DEA) refer to canine blood group systems that were originally defined by an international committee for canine immunogenetics, and were based on studies utilizing induced alloantibodies.

Detailed explanation-4: -The DEA 1 system appears to have more than one type, but DEA 1.1 in this blood group system has garnered the most clinical attention, as it is the most antigenic and is responsible for serious transfusion reactions. Approximately 50% of all dogs are positive for the DEA 1.1 antigen.

There is 1 question to complete.