THE MOLECULAR BASIS OF INHERITANCE
DNA MAKES RNA MAKES PROTEIN
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The protein would be produced in smaller quantities
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The protein would be denatured easily by high temperatures
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The protein would be shorter than expected
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The protein would be made of nucleotides instead of amino acids
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Detailed explanation-1: -A single nucleotide change results in the formation of a stop codon in the middle of a DNA sequence. Which of the following explains the effect on the protein produced from this gene? The protein would be shorter than expected.
Detailed explanation-2: -Definition. A nonsense mutation occurs in DNA when a sequence change gives rise to a stop codon rather than a codon specifying an amino acid. The presence of the new stop codon results in the production of a shortened protein that is likely non-functional.
Detailed explanation-3: -A stop codon is a codon that signals that the translation of a protein is complete and causes the ribosome to release the mRNA. If this happens in the middle of the sequence then the protein will not be fully transcribed. This may result in improper folding of the protein or complete destruction.
Detailed explanation-4: -An insertion changes the DNA sequence by adding one or more nucleotides to the gene. As a result, the protein made from the gene may not function properly.
Detailed explanation-5: -What happens when one nucleotide pair is lost from the middle of the coding sequence of a gene? The deletion of a nucleotide from the gene alters the reading frame downstream of the deleted base. This leads to the addition of incorrect amino acids in the polypeptide chain.