THE MOLECULAR BASIS OF INHERITANCE
DNA MAKES RNA MAKES PROTEIN
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Substitution because they shift the reading frame and cause downstream amino acids to be changed.
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Deletions because they shift the reading frame and cause downstream amino acids to be changed.
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Deletions because one protein is deleted.
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Neither type of mutation would cause a mis-translation of a protein.
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Detailed explanation-1: -A frameshift mutation is one that will most likely cause a change in the protein’s structure and function.
Detailed explanation-2: -Definition. A deletion, as related to genomics, is a type of mutation that involves the loss of one or more nucleotides from a segment of DNA. A deletion can involve the loss of any number of nucleotides, from a single nucleotide to an entire piece of a chromosome.
Detailed explanation-3: -Because an insertion or deletion results in a frame-shift that changes the reading of subsequent codons and, therefore, alters the entire amino acid sequence that follows the mutation, insertions and deletions are usually more harmful than a substitution in which only a single amino acid is altered.
Detailed explanation-4: -Frameshift mutations Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.