THE MOLECULAR BASIS OF INHERITANCE
DNA MAKES RNA MAKES PROTEIN
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The carbohydrate coded by the DNA has a different structure.
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The protein coded by the DNA has a different amino acid sequence.
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The chromosome carrying this gene changes shape during cell reproduction.
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The hormones in the blood are changed by increased differences in genes.
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Detailed explanation-1: -Sickle cell disease (SCD) is characterized by a single point mutation in the seventh codon of the -globin gene. Site-specific correction of the sickle mutation in hematopoietic stem cells would allow for permanent production of normal red blood cells.
Detailed explanation-2: -Mutations in the HBB gene cause sickle cell disease. The HBB gene provides instructions for making one part of hemoglobin. Hemoglobin consists of four protein subunits, typically, two subunits called alpha-globin and two subunits called beta-globin. The HBB gene provides instructions for making beta-globin.
Detailed explanation-3: -A mutation in the HBB gene causes hemoglobin to clump together and change the shape of red blood cells. This can lead to anemia and blocked blood flow for people with SCD. SCD can only be inherited if each parent passes down a mutated HBB gene. This means it is a recessive trait.
Detailed explanation-4: -Sickle cell disease is caused by mutations in the beta-globin (HBB) gene that lead to the production of an abnormal version of a subunit of hemoglobin-the protein responsible for carrying oxygen in red blood cells. This mutated version of the protein is known as hemoglobin S.