AP BIOLOGY

Detailed explanation-1: -Translocations. A translocation occurs when a piece of one chromosome breaks off and attaches to another chromosome. This type of rearrangement is described as balanced if no genetic material is gained or lost in the cell. If there is a gain or loss of genetic material, the translocation is described as unbalanced .

Detailed explanation-2: -A genetic change in which a piece of one chromosome breaks off and attaches to another chromosome. Sometimes pieces from two different chromosomes will trade places with each other.

Detailed explanation-3: -The four main types of structural chromosomal aberrations are deletion, duplication, inversion, and translocation.

Detailed explanation-4: -However, the mechanisms which cause these translocations remain poorly understood. Illegitimate V(D)J recombination, class switch recombination, homologous recombination, non-homologous end joining, and genome fragile sites all have potential roles in the production of non-random chromosomal translocations.