THE MOLECULAR BASIS OF INHERITANCE
DNA MAKES RNA MAKES PROTEIN
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Stability of mRNA
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Directs the movement of mRNA to a ribosome
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Helps transcription occur in the cytoplasm
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Helps transcription occur on the ribosome
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Detailed explanation-1: -5’ cap protects mRNA in the cytoplasm and helps in the attachment of mRNA with the ribosome for translation. Splicing removes introns from the protein-coding sequence of mRNA. Introns are regions that do not code for the protein. The remaining mRNA consists only of regions called exons that do code for the protein.
Detailed explanation-2: -The 5’ cap structure m7GpppN (where N is any nucleotide) is a ubiquitous feature of cellular eukaryotic mRNAs. The cap is multifunctional as it is involved in translation, nucleocytoplasmic transport, splicing, and stabilization of mRNA against 5’ exonucleolytic degradation.
Detailed explanation-3: -All eukaryotic mRNAs are capped at their 5′ end, shortly after transcription initiation. The cap consists of a guanine nucleotide methylated at the N7 position, and is linked to the 5′ nucleotide of the RNA through an unusual 5′-5′ pyrophosphate linkage (m7GpppN) (Shatkin, 1976; Furuichi and Shatkin, 2000).
Detailed explanation-4: -Eukaryotic translation initiation: Complex of small ribosomal subnit and initiator tRNA (bearing methionine) binds to 5’ cap of mRNA.