THE MOLECULAR BASIS OF INHERITANCE
DNA MAKES RNA MAKES PROTEIN
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Ligase
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Helicase
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DNA Polymerase
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RNA Polymerase
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Detailed explanation-1: -DNA helicases are essential during DNA replication because they separate double-stranded DNA into single strands allowing each strand to be copied. During DNA replication, DNA helicases unwind DNA at positions called origins where synthesis will be initiated.
Detailed explanation-2: -During replication, the helicase has to unwind a long stretch of DNA, and that requires the helicase to couple strand-separation activity to translocation. The mechanisms of these critical processes of the helicase reaction are largely unknown.
Detailed explanation-3: -Helicases are essential enzymes involved in all aspects of nucleic acid metabolism including DNA replication, repair, recombination, transcription, ribosome biogenesis and RNA processing, translation, and decay.
Detailed explanation-4: -DNA helicases catalyze the disruption of the hydrogen bonds that hold the two strands of double-stranded DNA together. This energy-requiring unwinding reaction results in the formation of the single-stranded DNA required as a template or reaction intermediate in DNA replication, repair and recombination.