THE MOLECULAR BASIS OF INHERITANCE
DNA MAKES RNA MAKES PROTEIN
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The DNA would not be copied into RNA.
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The RNA would not be copied into DNA.
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The mRNA would not be transferred to rRNA.
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The protein would not be assembled in the cytoplasm.
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Detailed explanation-1: -Which is the greatest consequence of transcription being blocked in the nucleus? The DNA would not be copied into RNA.
Detailed explanation-2: -The stalling of RNAP2 on lesions for extended periods of time can arrest cell cycle progression and lead to apoptosis [2], [3], and so, if TBLs remain unrepaired, this blocked transcription can cause severe cellular dysfunction, eventually resulting in DNA-damage-induced aging [4], [5], [6].
Detailed explanation-3: -However, errors that occur during transcription and translation can also have substantial effects on gene function by producing misfolded and malfunctioning proteins. The rate of translation errors is typically an order of magnitude higher than the rate of transcription errors (1–6).
Detailed explanation-4: -Errors in transcription can cause deleterious effect upon repeated translation of erroneous mRNA into protein. Transcription infidelity may result in aging and human diseases such as cancer.