AP BIOLOGY

THE MOLECULAR BASIS OF INHERITANCE

DNA MAKES RNA MAKES PROTEIN

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which of the following changes in DNA is likely to have the greatest effect on the resulting peptide?
A
in a strand of DNA, one C is changed to a T
B
a G is inserted at the beginning of a gene
C
a G is inserted at the end of a gene
D
in a strand of DNA, one T is changed to a C
Explanation: 

Detailed explanation-1: -Answer and Explanation: The type of mutation that is likely to have the greatest effect on a protein is B. Nonsense mutation. This is because a nonsense mutation creates a premature stop codon, leading to an incomplete formation of a protein, severely affecting protein structure and function.

Detailed explanation-2: -At the short end of the spectrum, indels of one or two base pairs within coding sequences have the greatest effect, because they will inevitably cause a frameshift (only the addition of one or more three-base-pair codons will keep a protein approximately intact).

Detailed explanation-3: -Which of the following is the most likely effect of a mutation in the gene coding for a DNA repair enzyme?-The cell containing the mutation will divide more frequently because the cell cycle checkpoints will not function properly.

Detailed explanation-4: -Point mutations are the most common type of mutation and there are two types.

There is 1 question to complete.