THE MOLECULAR BASIS OF INHERITANCE
DNA MAKES RNA MAKES PROTEIN
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
Deletion
|
|
|
Insertion
|
|
|
Duplication
|
|
|
Substitution
|
Detailed explanation-1: -An initiation codon mutation (AUG—-GUG) of the human alpha 1-globin gene. Structural characterization and evidence for a mild thalassemic phenotype.
Detailed explanation-2: -Mutations can be of many types, such as substitution, deletion, insertion, and translocation.
Detailed explanation-3: -It is a type of frameshift mutation characterized by the loss of one or more nucleotides from the segment of DNA. Example of deletion mutation is DiGeorge syndrome. DiGeorge syndrome is a disorder caused due to the deletion of a small segment of chromosome 22.
Detailed explanation-4: -The HTT mutation that causes Huntington disease involves a DNA segment known as a CAG trinucleotide repeat . This segment is made up of a series of three DNA building blocks (cytosine, adenine, and guanine) that appear multiple times in a row. Normally, the CAG segment is repeated 10 to 35 times within the gene.