THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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be unable to proofread the newly synthesized strand
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would make the DNA strands at incorrect locations
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be unable to unwind the DNA helix
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Detailed explanation-1: -Answer: Helicases are enzymes that disrupt the hydrogen bonds that hold the two DNA strands together in a double helix. This breakage exposes lengths of single-stranded DNA that will act as the template and are required for DNA replication. Therefore, the absence of helicases would prevent the replication process.
Detailed explanation-2: -During replication, the helicase has to unwind a long stretch of DNA, and that requires the helicase to couple strand-separation activity to translocation. The mechanisms of these critical processes of the helicase reaction are largely unknown.
Detailed explanation-3: -For DNA polymerases to function, the double-stranded DNA helix has to be unwound to expose two single-stranded DNA templates for replication. DNA helicases are responsible for unwinding the double-stranded DNA during chromosome replication.
Detailed explanation-4: -DNA replication requires other enzymes in addition to DNA polymerase, including DNA primase, DNA helicase, DNA ligase, and topoisomerase.