THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The leading strand is synthesized in the same direction as the movement of the replication fork, and the lagging strand is synthesized in the opposite direction.
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The leading strand is synthesized at twice the rate of the lagging strand.
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The leading strand is synthesized in short fragments that are ultimately stitched together, whereas the lagging strand is synthesized continuously.
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The leading strand is synthesized by adding nucleotides to the 3’ end of the growing strand, and the lagging strand is synthesized by adding nucleotides to the 5? end.
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Detailed explanation-1: -The leading strand is synthesized by adding nucleotides to the 3’ end of the growing strand, and the lagging strand is synthesized by adding nucleotides to the 5’ end. The lagging strand is synthesized continuously, whereas the leading strand is synthesized in short fragments that are ultimately stitched together.
Detailed explanation-2: -The major difference between a lagging and leading strand is that the lagging strand replicates discontinuously forming short fragments, whereas the leading strand replicates continuously.
Detailed explanation-3: -On the leading strand, DNA synthesis occurs continuously. On the lagging strand, DNA synthesis restarts many times as the helix unwinds, resulting in many short fragments called “Okazaki fragments.” DNA ligase joins the Okazaki fragments together into a single DNA molecule.
Detailed explanation-4: -One strand is synthesized continuously in the direction of the replication fork; this is called the leading strand. The other strand is synthesized in a direction away from the replication fork, in short stretches of DNA known as Okazaki fragments. This strand is known as the lagging strand.
Detailed explanation-5: -Due to the antiparallel orientation of the two chromosomal DNA strands, one strand (leading strand) is replicated in a mostly processive manner, while the other (lagging strand) is synthesized in short sections called Okazaki fragments.