AP BIOLOGY

THE MOLECULAR BASIS OF INHERITANCE

DNA REPLICATION

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
If a person suffered from a disorder where their DNA fragments were unable to fill in the missing slots in between the fragments of the lagging strand, they would most likely have a disorder that affected which enzyme?
A
DNA Helicase
B
DNA Ligase
C
DNA polyermase
D
RNA Polymerase
Explanation: 

Detailed explanation-1: -The major difference between a lagging and leading strand is that the lagging strand replicates discontinuously forming short fragments, whereas the leading strand replicates continuously.

Detailed explanation-2: -Proteins called single-strand binding proteins coat the separated strands of DNA near the replication fork, keeping them from coming back together into a double helix.

Detailed explanation-3: -DNA ligase I is responsible for joining Okazaki fragments together to form a continuous lagging strand.

Detailed explanation-4: -Answer and Explanation: The production of Okazaki fragments in the lagging strand during replication of DNA is necessary because the new strand synthesis happens in the direction of 3’ to 5’ direction. Still, the DNA polymerase can synthesize the strand only in the 5’ to 3’ direction.

There is 1 question to complete.