THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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DNA Polymerase
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Ligase
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RNA primase
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Helicase
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Detailed explanation-1: -Okazaki fragments are short sequences of DNA nucleotides (approximately 150 to 200 base pairs long in eukaryotes) which are synthesized discontinuously and later linked together by the enzyme DNA ligase to create the lagging strand during DNA replication.
Detailed explanation-2: -The DNA (deoxyribonucleic acid) ligase enzyme functions to join (or link) the Okazaki fragments by forming phosphodiester bonds (covalent bonds) between the fragments. This way the enzyme can seal the nicks. The said enzyme also helps to repair breaks and thus, is an essential part of the DNA repair process.
Detailed explanation-3: -There is compelling evidence that DNA ligase I is predominantly responsible for joining Okazaki fragments generated by discontinuous DNA synthesis on the lagging strand at the replication fork.