THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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synthesizes the RNA primer, initiates DNA synthesis and the lagging strand
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Repair DNA
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replicate mitochondrial DNA
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synthesizes the leading strand, filling DNA gaps after removal of primer
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Detailed explanation-1: -Mitochondrial DNA is replicated and repaired by DNA polymerase (Pol ). Pol , encoded by the POLG gene, is the only polymerase found in animal cell mitochondrial and is involved in replication, mutagenesis, and repair of mtDNA as well is a target of antiviral nucleoside analogs that cause mitochondrial toxicity.
Detailed explanation-2: -mtDNA replication factors DNA polymerase (POL) is the replicative polymerase in mitochondria. In human cells, POL is a heterotrimer with one catalytic subunit (POLA) and two accessory subunits (POLB) [3–5].
Detailed explanation-3: -Replication. Mitochondrial DNA is replicated by the DNA polymerase gamma complex which is composed of a 140 kDa catalytic DNA polymerase encoded by the POLG gene and two 55 kDa accessory subunits encoded by the POLG2 gene. The replisome machinery is formed by DNA polymerase, TWINKLE and mitochondrial SSB proteins.
Detailed explanation-4: -Mitochondrial DNA (mtDNA) polymerase gamma (Polg) is a heterodimeric enzyme containing a Pol I-like catalytic core (PolgA) and an accessory subunit. Mutations in POLGA, affecting the stability of mtDNA, have been identified in several human pathologies such as progressive external ophthalmoplegia and Alpers’ syndrome.
Detailed explanation-5: -Eukaryotic cells contain five DNA polymerases: , , ,