THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The direction new nucleotides are synthesized on the new strand
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5’ to 3’ (new nucleotides added to the 3’ end)
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3’ to 5’ (new nucleotides added to the 5’ end)
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Explanation:
Detailed explanation-1: -DNA is always synthesized in the 5’-to-3’ direction, meaning that nucleotides are added only to the 3’ end of the growing strand. As shown in Figure 2, the 5’-phosphate group of the new nucleotide binds to the 3’-OH group of the last nucleotide of the growing strand.
Detailed explanation-2: -DNA polymerase is able to add nucleotides only in the 5’ to 3’ direction (a new DNA strand can be only extended in this direction). It also requires a free 3’-OH group to which it can add nucleotides by forming a phosphodiester bond between the 3’-OH end and the 5’ phosphate of the next nucleotide.
Detailed explanation-3: -DNA replication always happens in the 5’
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