THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
The Okazaki fragments are joined together by ____
|
|
Helicase
|
|
|
DNA ligase
|
|
|
Single-stranded binding protein
|
|
|
Topoisomerase
|
Explanation:
Detailed explanation-1: -Okazaki segments are joined by DNA ligase .
Detailed explanation-2: -On the lagging strand, DNA synthesis restarts many times as the helix unwinds, resulting in many short fragments called “Okazaki fragments.” DNA ligase joins the Okazaki fragments together into a single DNA molecule. Helicase opens up the DNA at the replication fork.
Detailed explanation-3: -There is substantial biochemical evidence indicating that DNA ligase I, which is one of four DNA ligases in mammalian cells (1, 2), is the enzyme responsible for joining Okazaki fragments.
There is 1 question to complete.