THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Primase is not required
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RNA primers are not required
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DNA ligase is not needed.
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DNA synthesis proceeds in the 3´ to-5´ direction.
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Detailed explanation-1: -Answer and Explanation: The replication of lagging strands of DNA differs from the replication of leading strands in that: e. DNA is replicated as short fragments. This occurs due to the orientation of the lagging DNA strand and result in the formation of short segments called Okazaki fragments.
Detailed explanation-2: -The lagging strand is synthesized continuously, whereas the leading strand is synthesized in short fragments that are ultimately stitched together. The leading strand is synthesized at twice the rate of the lagging strand. one RNA primer attaches to the 5’ end of the parent strand and the other primer to the 3’ end.
Detailed explanation-3: -The need for accuracy probably explains why DNA replication occurs only in the 5′-to-3′ direction. If there were a DNA polymerase that added deoxyribonucleoside triphosphates in the 3′-to-5′ direction, the growing 5′-chain end, rather than the incoming mononucleotide, would carry the activating triphosphate.
Detailed explanation-4: -Leading Strand and Lagging Strand The other strand is called the lagging strand. This is the parent strand that runs in the 5’ to 3’ direction toward the fork, and it’s replicated discontinuously.
Detailed explanation-5: -The major difference between a lagging and leading strand is that the lagging strand replicates discontinuously forming short fragments, whereas the leading strand replicates continuously.