THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The stem cells in your intestinal walls divide frequently. Therefore, these cells are likely to
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Have high levels of telomerase
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Have very low levels of telomerase
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Lack DNA polymerase
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Lack Okazaki Fragments
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Explanation:
Detailed explanation-1: -In adult stem cells, the level of telomerase activity is low or undetectable, and upregulated in committed progenitor cells which have high reproducible activity in each tissue but insufficient to stably maintain their telomere length.
Detailed explanation-2: -Indeed, we find that intestinal stem cells contain significant telomerase activity and that this activity is gradually lost in their progeny. The level of telomerase activity is comparable to the immortal diploid colorectal cancer cell line DLD1.
Detailed explanation-3: -High telomerase activity is associated with cell cycle deregulation and rapid progression in endometrioid adenocarcinoma of the uterus. Hum Pathol.
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