THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The origins of replication occur only at the 5’ end.
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helicases and single-strand binding proteins work at the 5’ end.
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DNA polymerase can join new nucleotides only to the 3’ end of a growing strand.
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DNA ligase works only in the 3’ to 5’ direction.
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Detailed explanation-1: -The leading strand synthesized in the 5’ to 3’ direction. The lagging strand synthesized in the 3’ to 5’ direction. Nucleotides of the leading strand are joined by the DNA polymerase. It only attaches at the 3’end of the growing strand.
Detailed explanation-2: -The major difference between a lagging and leading strand is that the lagging strand replicates discontinuously forming short fragments, whereas the leading strand replicates continuously.
Detailed explanation-3: -The lagging strand is synthesized continuously, whereas the leading strand is synthesized in short fragments that are ultimately stitched together. The leading strand is synthesized at twice the rate of the lagging strand. one RNA primer attaches to the 5’ end of the parent strand and the other primer to the 3’ end.