THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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DNA is synthesized in a 5’ to 3’ direction on the lagging strand and a 3’ to 5’ direction on the leading strand
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DNA is synthesized in a 3’ to 5’ direction on the lagging strand and a 5’ to 3’ direction on the leading strand
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DNA is synthesized continuously on the leading strand and discontinuously on the lagging strand
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DNA is synthesized discontinuously on the leading strand and continuously on the lagging strand
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Detailed explanation-1: -The separated DNA strands form a replication fork, where both the DNA strands get replicated forming a lagging and leading strand. The major difference between a lagging and leading strand is that the lagging strand replicates discontinuously forming short fragments, whereas the leading strand replicates continuously.
Detailed explanation-2: -The lagging strand is synthesized continuously, whereas the leading strand is synthesized in short fragments that are ultimately stitched together. The leading strand is synthesized at twice the rate of the lagging strand. one RNA primer attaches to the 5’ end of the parent strand and the other primer to the 3’ end.
Detailed explanation-3: -On the leading strand, DNA synthesis occurs continuously. On the lagging strand, DNA synthesis restarts many times as the helix unwinds, resulting in many short fragments called “Okazaki fragments.” DNA ligase joins the Okazaki fragments together into a single DNA molecule.
Detailed explanation-4: -Lagging-strand replication is discontinuous, with short Okazaki fragments being formed and later linked together.
Detailed explanation-5: -Therein lies the main difference between the two: A leading indicator looks forward at future outcomes and events. A lagging indicator looks back at whether the intended result was achieved.