THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Synthesizing RNA primers
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Ensure both strands are replicated at similar rates
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Prevent the separated strands from reannealing
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Recruit DNA polymerase
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Detailed explanation-1: -In order to manufacture the new strands, the two original strands must be kept apart. This is done by single strand binding protein, or SSB protein, which binds to the unpaired single-stranded DNA and prevents the two parental strands from reannealing.
Detailed explanation-2: -During DNA replication, the single-stranded DNA binding protein (SSB) wraps single-stranded DNA (ssDNA) with high affinity to protect it from degradation and prevent secondary structure formation.
Detailed explanation-3: -Single strand binding protein (ssb protein) binds to separated strands of DNA and prevents reannealing.
Detailed explanation-4: -As single-stranded DNA binding proteins are utilized in some of the most important aspects of DNA metabolism, they are used extensively in DNA replication, repair and recombination. Most SSBs use one or more subunits with an OB-fold motif to bind securely and preferentially to ssDNA.
Detailed explanation-5: -Replication Protein A (RPA), the major single-stranded DNA-binding protein in eukaryotic cells, is required for processing of single-stranded DNA (ssDNA) intermediates found in replication, repair and recombination.