THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
To enable replication of the 3’
|
|
|
To form the template for the RNA primers
|
|
|
To initiate replication on the 5’
|
|
|
To help the DNA helicase unwinding the DNA helix
|
Detailed explanation-1: -These fragments are formed on the lagging strand for the synthesis of DNA. The direction is 5’ to 3’ toward the replication fork. These fragments make the replication of only one of the two strands possible hence increasing the efficiency of replication.
Detailed explanation-2: -Okazaki fragments are short sequences of DNA nucleotides (approximately 150 to 200 base pairs long in eukaryotes) which are synthesized discontinuously and later linked together by the enzyme DNA ligase to create the lagging strand during DNA replication.
Detailed explanation-3: -A new DNA strand only grows in the 5’ to 3’ direction because the enzyme that adds new bases to a growing strand requires a free 3’ OH group. The sugar-phosphate backbone of DNA is made up of phosphodiester linkages between 3’ OH groups and 5’ phosphate groups.
Detailed explanation-4: -The lagging strand is a single DNA strand that, during DNA replication, is replicated in the 5′ – 3′ direction (opposite direction to the replication fork).