AP BIOLOGY

THE MOLECULAR BASIS OF INHERITANCE

DNA REPLICATION

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which enzyme fixes the Okazaki fragments by “gluing them together” in the lagging strand?
A
Helicase
B
Polymerase
C
Ligase
D
Primerase
Explanation: 

Detailed explanation-1: -Ultimately, the Okazaki fragments are joined together by an enzyme DNA ligase .

Detailed explanation-2: -DNA ligase I is responsible for joining Okazaki fragments together to form a continuous lagging strand.

Detailed explanation-3: -The Okazaki fragments must be attached together into one continuous strand after replication. This is accomplished by the enzyme DNA ligase, which seals the sugar phosphate backbone of the Okazaki fragments.

Detailed explanation-4: -The strand with the Okazaki fragments is known as the lagging strand. As synthesis proceeds, an enzyme removes the RNA primer, which is then replaced with DNA nucleotides, and the gaps between fragments are sealed by an enzyme called DNA ligase.

Detailed explanation-5: -Answer and Explanation: DNA ligase glues together the fragments produced on the lagging strand of DNA during replication. After the RNA primers are removed from the 5’ end of each Okazaki fragment, a DNA polymerase fills in the gap with deoxyribonucleotides (dNTPs).

There is 1 question to complete.