THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which enzyme seals okazaki fragments together on the lagging strand?
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Topoisomerase
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Helicase
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Polymerase
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Ligase
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Explanation:
Detailed explanation-1: -There is compelling evidence that DNA ligase I is predominantly responsible for joining Okazaki fragments generated by discontinuous DNA synthesis on the lagging strand at the replication fork.
Detailed explanation-2: -DNA ligase is the protein responsible for linking, or ligating, Okazaki fragments together in order to form a single complete DNA strand.
Detailed explanation-3: -Abstract. DNA ligase 1 (LIG1, Cdc9 in yeast) finalizes eukaryotic nuclear DNA replication by sealing Okazaki fragments using DNA end-joining reactions that strongly discriminate against incorrectly paired DNA substrates.
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