THE MOLECULAR BASIS OF INHERITANCE
DNA REPLICATION
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
Topoisomerases work ahead of the replication fork to prevent supercoiling.
|
|
|
DNA polymerase I opens up the DNA at the replication fork.
|
|
|
Helicase seals gaps between DNA fragments.
|
|
|
DNA primase extends primers by adding nucleotides to the 3’ end.
|
Detailed explanation-1: -Which of the following correctly pairs the DNA replication enzyme with its function? Topoisomerases work ahead of the replication fork to prevent supercoiling. Topoisomerase prevents the DNA double helix ahead of the replication fork from getting too tightly wound as the DNA is opened up.
Detailed explanation-2: -Which of the following correctly pairs the DNA replication enzyme with its function? Helicase opens up the DNA at the replication fork.
Detailed explanation-3: -Topoisomerases play critical roles in DNA replication, transcription, and chromosome structure by altering the topological state of DNA, . These enzymes are capable of relaxing supercoiled DNA and of decatenating interlocked DNA (Fig.
Detailed explanation-4: -Topoisomerase I is proposed to work ahead of the replication fork to remove positive DNA supercoils, whereas topoisomerase II is proposed to work primarily behind the fork to remove precatenanes. In contrast to replication models, drug models place topoisomerase II ahead of DNA tracking systems.
Detailed explanation-5: -The order of enzymes in DNA replication include the following: DNA helicase, RNA primase, DNA polymerase, and finally DNA ligase.